Masachika Ichimura was the first to voice the original Mewtwo character in Japanese, and the creature's younger self is voiced by Fujiko Takimoto in the Sound Picture Box: Mewtwo's Origin CD drama and Showtaro Morikubo in the anime adaptation. Mewtwo has also appeared in various animated adaptations of the franchise. It is known as the 'Genetic Pokémon' and is a Legendary Pokémon, a special group of Pokémon that are very rare and usually very powerful. Mewtwo is regarded as one of the series' strongest Pokémon, and was the strongest in the original games in terms of base statistic distribution. The player first learns of Mewtwo late in Pokémon Red and Blue by reading research documents left in a ruined laboratory on Cinnabar Island.

In the video games, the player can fight and capture Mewtwo in order to subsequently pit it against other Pokémon. Created by Ken Sugimori, it debuted in the video games Pokémon Red and Blue, and later appeared in subsequent sequels and spin-off titles, such as Pokken Tournament. Mewtwo is a Pokémon, a fictional creature from Nintendo and Game Freak.

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